Several studies report the term bone debris as a “danger signal” because it contains coagulation activators which could contribute to the processes of hemostasis cascades leading to the formation of DVT, namely collagen, proteoglycan, fibronectin, von Willebrand Factor (vWF), and Tissue Factor (TF) [12], besides P-selectin (Ps) and Nitric Oxide (NO) [13,14]. This evidence concerns the gene F3 and deep vein thrombosis.