Dedicator of Cytokinesis 8 (DOCK8) deficiency is an autosomal recessive CID presenting with severe eczema [Fig. 3], severe allergies, immunodeficiency with increased susceptibility to bacterial, fungal, and viral infections, autoimmunity, neurological manifestations, cerebral vascular malformations and increased risk for malignancies.31 The gene discussed is DOCK8; the disease is allergic disease.