As reported for WAS and WAS-like conditions, several IPEX-like syndromes have been described in the last years,116 including CD25 deficiency, STAT5b deficiency, and Itchy E3 Ubiquitin Protein Ligase (ITCH) deficiency [Table 3]. This evidence concerns the gene UBE2E3 and hyperinsulinemic hypoglycemia, familial, 4.