Comèl-Netherton syndrome is also classified among the inherited skin disorders sharing pathogenetic pathways with atopic conditions48 together with ichthyosis vulgaris caused by null mutations in Filaggrin (FLG),49 the inflammatory peeling skin syndrome due to mutations in Corneodesmosin (CDSN),50 the severe skin dermatitis, multiple allergies and metabolic wasting (SAM) syndrome due to bi-allelic mutations in DSG1, encoding the desmosomal cadherin desmoglein 1 (DSG1),51 or in DSP, encoding another desmosomal protein, desmoplakin.52 This evidence concerns the gene DSG1 and skin disorder.