Indeed, despite the transient expansion in numbers, both peripheral and rectal γδT cells displayed a significant decline in IL-17 and IL-22 cytokine responses indicating that a specific decline in γδT IL-17/IL-22 effector functions, besides the significant gut mucosal Th17 depletion, likely contributed to the overall loss of epithelial barrier integrity during acute phase of infection. The gene discussed is IL17A; the disease is infection.