IGKV1D-22 and Insulin resistance: Similarly to Gipr-/- BM, LysMΔGipr mice exhibit an aggravated metabolic phenotype in response to prolonged HFD, associated with increased weight gain, steatohepatitis, insulin resistance, myelopoiesis and S100A8/A9 production, as well as impaired ingWAT beiging (13).