Similarly to Gipr-/- BM, LysMΔGipr mice exhibit an aggravated metabolic phenotype in response to prolonged HFD, associated with increased weight gain, steatohepatitis, insulin resistance, myelopoiesis and S100A8/A9 production, as well as impaired ingWAT beiging (13). This evidence concerns the gene S100A8 and Insulin resistance.