GIPR and Hepatic steatosis: In contrast to the overall metabolic protection of mice with stimuli global germline inactivation of the GIPR (14), bone marrow (BM) chimeric mice with immune cell-targeted GIPR-deficiency (Gipr-/- BM) display greater weight gain during HFD feeding, despite similar food intake, concomitantly with increased insulin resistance and hepatic steatosis (13).