Similar to the results obtained during the development of obesity (Figure 3B), the reduced expression of Il33 and Penk in the epiWAT of Gipr-/- BM mice was restored to WT BM control levels in Gipr-/-S100a9-/-BM mice (Figure 3H). The gene discussed is PENK; the disease is obesity due to melanocortin 4 receptor deficiency.