This SNP has also been associated with increased risk for multiple autoimmune diseases including rheumatoid arthritis (RA) (28), systemic lupus erythematosus (SLE) (53), Graves’ disease (52, 54), myasthenia gravis (55), primary Sjogren’s syndrome (56), generalized vitiligo (57), Addison’s disease (58), and alopecia areata (59) strongly suggesting PTPN22 regulates immunity. The gene discussed is PTPN22; the disease is systemic lupus erythematosus.