IFNA2 and systemic lupus erythematosus: This effect is not limited to TLR4 stimulation, plasmacytoid dendritic cells (pDCs) from PTPN22620W/W and PTPN22620R/W patients with SLE have reduced IFNα production following R848 (TLR7/8 agonist) stimulation compared to PTPN22620R/R patients (PTPN22620R/W+PTPN22620W/W; ~35% pDCs IFNα2+ with gMFI of ~250 vs. PTPN22620R/R; 45% pDCs IFNα2+ with gMFI of ~500) (122).