In contrast to function of preventing excessive antigen reduction characterized in previous section, NOX2-derived ROS in the degradation of apoptotic cells seems to be a positive correlation: efferosomes maturation (acquisition of LC3 and LAMP-1), enhanced acidic environment mediated by V-ATPases, competent proteolytic activity, and these are obviously delayed in macrophage of CGD patients. This evidence concerns the gene CYBB and chronic granulomatous disease.