A separate study observed an increase in CD4+CD25+ T cells in MGUS and MM, but a decrease in FOXP3+ Treg cells; these Tregs also appeared dysfunctional with a decreased ability to suppress T-cell proliferation, potentially contributing to a non-specific increase in T cells and dysfunctional anti-tumor immunity (101). This evidence concerns the gene FOXP3 and Miyoshi myopathy.