Of note, the involvement of macrophages in COVID-19 and the therapeutic potential of SPMs in the disease is further highlighted in a recent study; short incubation (3h) of monocyte-derived macrophages isolated from cystic fibrosis (CF) individuals with S1, S2 and N proteins from SARS-CoV-2 resulted in rapid release of chemokines such as IL-8 in cell-free supernatants (71). Here, CXCL8 is linked to cystic fibrosis.