Furthermore, downregulation of LGR5 in FP (log2FoldChange = −4.56, padj = 1.03 × 10−9) may also demonstrate evidence of an anti-tumor response through regulation of the Wnt/β-catenin signaling pathway, as increased expression of LGR5 is associated with poor prognosis in glioma (70), breast cancer (71) and oral squamous cell carcinoma (72). Here, LGR5 is linked to central nervous system cancer.