Nevertheless, using REV-ERBα –/– mice, increased NLRP3 and IL-1β expression was detected, and REV-ERBα was linked to experimental colitis through its ability to repress the expression of p65 subunit of NFkB, which subsequently leads to the suppression of NLRP3 inflammasome at the priming level (100). This evidence concerns the gene NR1D1 and colitis.