Nevertheless, using REV-ERBα –/– mice, increased NLRP3 and IL-1β expression was detected, and REV-ERBα was linked to experimental colitis through its ability to repress the expression of p65 subunit of NFkB, which subsequently leads to the suppression of NLRP3 inflammasome at the priming level (100). The gene discussed is NFKB1; the disease is colitis.