Interestingly, while Dnase2a-Tmem173 (gene encoding STING) double KO mice were healthy (112, 113) Dnase2a-Ifnar1 double-KO mice develop rheumatoid arthritis that was driven by TNFα (Tumor Necrosis Factor-α) (109, 110). This evidence concerns the gene DNASE2 and rheumatoid arthritis.