Nevertheless, further investigation is needed to identify endogenous RNAs regulated by SKIV2L and its relevance in the control of the immunostimulatory potential of endogenous RNA in vivo, since SKIV2L hypomorphic mutations in humans are associated with tricohepatoenteric syndrome a rare congenital bowel disorder (145) and not severe autoimmunity. This evidence concerns the gene SKIC2 and Autoimmunity.