In addition, cytokines and chemokines secreted by polyfunctional T cells, including IFN-γ, MIP-1, IL-8, granzyme B, IL-17A, and IL-5, can mitigate immunosuppression caused by the tumor microenvironment and improve the clinical response in CD19 CAR-T cell therapy (49). This evidence concerns the gene CD19 and neoplasm.