NKG2DL upregulation and NKG2D signaling activation in effector CD8 T cells play a role in the onset or development of some autoimmune diseases, including vitiligo, rheumatoid arthritis, celiac disease, type 1 diabetes, alopecia areata, systemic lupus erythematosus (SLE), among others (36–41). Here, KLRK1 is linked to autoimmune disease.