More recent studies by Li et al. found that circFADS2 (hsa_circRNA_100833) acts as an inhibitor of miR-498/mTOR cross-talk by directly targeting miR-498, regulating extracellular matrix (ECM) catabolism, inflammation, and apoptosis, and affecting the pathophysiological process of RA. This evidence concerns the gene MTOR and rheumatoid arthritis.