Circ-DNMT1 (hsa_circ_0049224) interacts with p53 and AUF1 to promote the complex to enter the nucleus, and the AUF1 protein cannot inhibit DNMT1 mRNA after entering the nucleus, leading to the accumulation of the DNMT1 protein, which inhibits p53 transcription, and the promotion of the gene expression related to tumor proliferation (91). The gene discussed is TP53; the disease is neoplasm.