Zhang et al. discovered that hsa_circ_0012919 was downregulated by competitively binding to miR-125a-3p in patients with SLE, reversing the DNA hypomethylation of CD11a and CD70 in CD4+ T cells, increasing the expression of DNMT1, and reducing the expression of CD70 and CD11a. This evidence concerns the gene CD4 and systemic lupus erythematosus.