Interestingly, Li et al. demonstrated that hsa_circ_0045272 was significantly downregulated, which would result in certain miRNAs being free and the subsequent downregulation of NM_003466 (PAX8) and NM_015177 (DTX4) mRNAs, thereby negatively regulating the production and apoptosis of interleukin-2 (IL-2) in the T cells of patients with SLE (55). This evidence concerns the gene IL2 and systemic lupus erythematosus.