Xu argued for the first time that the increase in hsa-circ-0001045 in the synovial tissues of patients with RA significantly inhibits miR-30a, resulting in the overexpression of Beclin-1 and LC3 in RA and thereby reducing apoptosis and promoting the occurrence and development of RA (64). The gene discussed is MAP1LC3A; the disease is rheumatoid arthritis.