PIN1 and rheumatoid arthritis: In fact, except for some cancers, Pin1 also plays an important role in asthma development and in the response to microbial infection besides rheumatoid arthritis (RA), Systemic Lupus Erythematosus (SLE) and nonalcoholic steatohepatitis (NASH) (39–44), suggesting that Pin1 is closely related to certain inflammatory reactions.