CD8A and neoplasm: In the tumor microenvironment, Il-10 could inhibit macrophage cytokine synthesis and their antigen-presenting capacity (23). On the other hand, IL-10 showed stimulating roles in tumor-resident CD8+T cell through inducing cytotoxicity of CD8+ T cells and leads to an increase in the expression of IFN-γ in CD8+ T cells (24).