Meanwhile, IL-10 shows stimulating roles in tumor-resident CD8+ T cell through expanding cytotoxicity of CD8+ T cells and leading to an increase in the expression of IFN-γ in CD8+ T cells, and the inhibition of T-cell trafficking from lymphoid organs does not impair IL-10-induced activation of tumor-resident CD8+ T cells (24). This evidence concerns the gene IFNG and neoplasm.