CD8+ T cells from both IL-10 and Ad-hTERT treatment produced more sufficient IFN-γ compared with PBS, and the combination therapy showed the most efficient role through presenting twenty or thirty times higher level of IFN-γ level compared with the PBS control group in LLC or B16F10 tumor-bearing mice respectively (Figures 4E, F). The gene discussed is IL10; the disease is neoplasm.