The NKG2D/ligand interaction is likely to contribute to the reciprocal effects of NK cells and other cells in atherosclerosis, as it has been demonstrated that NKG2D ligand levels are upregulated in multiple organs in mouse models, particularly atherosclerotic aortae and inflamed livers, where accumulated abnormal metabolites and increased NK cell numbers could also be observed (92). The gene discussed is KLRK1; the disease is atherosclerosis.