PADI4 and bacterial infectious disease with sepsis: However, although NETs were first postulated to limit infection, a lack of NETs did not worsen bacteremia in PAD4-deficient mice which were subjected to polymicrobial sepsis, indicating that NET inhibition will not likely render the host vulnerable to bacterial infections (62). However, further research is necessary to validate our findings in humans and to test tolerances of the DNases in a clinical setting.