In IL-17-dependent cGVHD models of scleroderma and bronchiolitis obliterans, donor bone marrow-derived macrophages were found infiltrating the skin and lung in a CSF-1/CSF-1R-, but not CCL2/CCR2- or GM-CSF/GM-CSFR-, dependent manner and contribute to the pathogenesis of cGVHD. This evidence concerns the gene IL17A and scleroderma.