The frequencies of T/T genotype at rs733618 and the A/A genotype at rs231775 and rs3087243 of CTLA-4 were significantly higher in PSS patients than in healthy controls, but did not survive the FDR correction (51.82 vs. 35.52%, p = 0.005, corrected p (Pc) = 0.082, OR = 1.81; 21.90 vs. 9.35%, p = 0.004, Pc = 0.122, OR = 2.72; 8.76 vs. 2.88%, p = 0.037, Pc = 0.37, OR = 3.24, respectively). The gene discussed is CTLA4; the disease is peeling skin syndrome.