The frequencies of T allele at rs733618 and A allele at rs231775 of CTLA-4 were significantly higher in PSS patients than in healthy controls, and these associations survived the FDR correction (70.80 vs. 58.99%, Pc = 0.037, OR = 1.56; 40.88 vs. 30.22%, Pc = 0.044, OR = 1.55, respectively). Here, CTLA4 is linked to peeling skin syndrome.