Zhang et al. found that enhanced T-helper (TH)17 cells coupled with IL-17 cytokines correlated with an elevated M1/M2 macrophages ratio at the local mucosal site of MRONJ lesion and that the inhibition of IL-17 activity reduced the elevated M1/M2 macrophages ratio as well as the incidence of MRONJ-like lesions in mice with multiple myeloma. This evidence concerns the gene IL17A and AL amyloidosis.