Then early activation of TIGIT+NK and TIGIT−NK cells may lead to the depletion of CD4 T cells in acute and chronic HIV-1 infection, especially in the first month of infection (TIGIT+NK: r = −0.72, P = 0.001; TIGIT−NK: r = −0.66, P = 0.004). The gene discussed is TIGIT; the disease is HIV-1 infection.