IFNG and HIV-1 infection: Indeed, NKG2A+NK cells from HIV-1-uninfected individuals are implicated in better control of HIV-1 infection in in vitro models, as NKG2A+NK cells exhibit higher response and a polyfunctional profile of CD107a, IFN-γ, and CCL4 production in response to HLA-null cells and infected CD4+ T-cells compared to NKG2A−NK cells (39).