The quantity, intensity and even multifunctionality of TIGIT+NK cells releasing CD107a, IFN-γ, and TNF-α in response to K562 cells were reduced compared to those of TIGIT−NK cells in both HIV-1-infected individuals and HIV-1-uninfected donors, suggesting that the potential effect of TIGIT-expressing NK cells on inhibiting HIV-1 infection might be weaker. The gene discussed is TIGIT; the disease is HIV-1 infection.