TIGIT and infection: TIGIT+NK cells harbored proliferated cells comparable to the TIGIT−NK cells in HIV-1-negative donors and in HIV-1-infected individuals in the first and third months of infection but fewer expanded cells among TIGIT−NK cells in the twelfth month of infection (Figure 5F, P = 0.031) and in chronic infection over 2 years (Figure 5F, P = 0.007).