Sixty-three-year-old male with a background of traumatic below knee amputation developed DRESS syndrome characterized by periorbital oedema, maculopapular rash, eosinophilia (0.69 x109/L) and hepatitis (ALT 347 U/ml) 1 week after commencement of meropenem and vancomycin for treatment of cellulitis. The gene discussed is GPT; the disease is drug hypersensitivity syndrome.