Another study using adoptive transfer of OT-I (high-affinity) and OT-3 (low-affinity) transgenic tumor-specific CD8+ T cells was able to demonstrate that OT-3 T cells were able to mediate tumor regression in pancreas with minimum autoimmunity, contrast to OT-I T cells which in addition to the rapid eradication of the tumor, caused autoimmune diabetes in the mouse model (314). Here, CD8A is linked to neoplasm.