HGF and neoplasm: In addition, the newly identified PGC, C7, HGF, PLA2G2A, IL1RL1, CCR2, ALOX15B, CXCL11, and FCN3 genes, which were down-regulated in the TSG mutated group, were key immune genes which might be involved in the crosstalk between cancer microenvironment and tumor suppressors.