In addition, the newly identified PGC, C7, HGF, PLA2G2A, IL1RL1, CCR2, ALOX15B, CXCL11, and FCN3 genes, which were down-regulated in the TSG mutated group, were key immune genes which might be involved in the crosstalk between cancer microenvironment and tumor suppressors. This evidence concerns the gene ALOX15B and neoplasm.