NFKB1 and neoplasm: Previously, it was confirmed that the overexpression of interleukin 12 (IL12) induced the tumor-suppressive effect by mediating antitumor activity, and mutated tumor suppressor genes such as TP53 potentially regulated the immune cell infiltration through its interaction with NF-kB and prevented activation of cytotoxic T cells, NK cells, and macrophages (38, 41, 42).