In addition to cytotoxic T cells, activated natural killer (NK) cells, T helper 17 cells (Th17), and APCs also contribute to the release of IL-5, IL-6, IL-12, IL-15, IL-17, IL-18, further exacerbating the extensive collateral damages and result in SJS/TEN (27, 32). This evidence concerns the gene IL15 and toxic epidermal necrolysis.