CCL17 and Increased total eosinophil count: On the other hand, when the activation of certain drug-specific T helper 2 (Th2) lymphocytes occurs with the reactivation of human herpes virus (HHV)-6, HHV-7, Epstein–Barr virus (EBV), or CMV, these T cells are thought to further release IL-4, IL-5, and IL-13 which work together with eotaxin, thymus activation-regulated chemokine (TARC), and pro-inflammatory cytokines such as IFN-γ, TNF, IL-6, and IL-15, promoting systemic inflammation with eosinophilia and resulting in DRESS/DIHS (15, 33–36).