Notably, a recent study demonstrated in cortical specimens from patients suffering from frontotemporal lobar degeneration associated to an increase availability of anti-GluA3 auto-antibodies the onset of postsynaptic changes in the expression of scaffolding proteins (e.g., the GRIP1/PICK1 ratio) involved in AMPA receptor retention/internalization (27). This evidence concerns the gene GRIA3 and frontotemporal dementia.