Additionally, we found the proportion of ILC3s co-expressing IL-22 and CCR6 (IL-17 producing ILC3s) in kidney of MRL/lpr mice was elevated with the development of LN, indicating that ILC3s simultaneously produced IL-17, which is acknowledged as pro-inflammatory cytokine for LN, and promote the development of LN. The gene discussed is IL17A; the disease is lobular neoplasia.