By RNA-Seq, we found that gene expression of local chemokines in the kidney of lupus-prone mice was altered, and qRT-PCR further confirmed down-regulated expression of CXCL1, CCL2, and CXCL10 in the kidney of IL-22 or IL-22R KO MRL/lpr mice compared with MRL/lpr mice. Here, IL22 is linked to systemic lupus erythematosus.