PDE4B and neoplasm: Of the ohnolog pairs with evidence of divergent gene expression profiles, such genes were annotated with a range of immunological function, including antiviral defense (DHX58, zinc finger protein 148), apoptosis (RAC2), inflammation regulation (MAPK8, PDE4B, Roquin-1), anti-microbial response (Akirin-2, ARHGEF2), T-cell activation (LCK, HLX) as well as tumor suppression (PRKCA, FAM49B, IMPDH1).