IL18 and HIV-1 infection: With regard to plasma markers an elevated concentration of circulating IL-18 in ART patients [median 534,8 pg/ml, (290,9–1478)] compared to EC [336 pg/ml, (149,1–412,1)] was observed (Supplementary Figure 1A), suggesting that systemic inflammation stays elevated during ART and in contrast is more limited during natural control of HIV-1 infection.