We found that infants with clinical or blood-culture proven early-onset sepsis (EOS, n = 24) had higher levels of all galectins at day 1 of life compared to unaffected preterm infants (no EOS, n = 73); (gal-1 (ng/ml) EOS: 112.9 ± 101.7 versus no EOS: 80.9 ± 65.4; P = 0.018, Figure 2A; gal-3 (ng/ml) EOS: 15.2 ± 12.2 versus no EOS: 10.1 ± 7.5, P = 0.036, Figure 2C; gal-9 (ng/ml) EOS: 3.8 ± 2.9 versus no EOS: 2.9 ± 2.5; P = 0.049, Figure 2E). Here, LGALS3 is linked to Sepsis.