Dectin-1 has been shown to contribute to host resistance against multiple forms of C. albicans-driven candidiasis (Ferwerda et al., 2009; Plantinga et al., 2009, 2010), however, we recently showed that the requirement for Dectin-1 for specific immune responses to Candida is species-dependent. The gene discussed is CLEC7A; the disease is candidiasis.