Furthermore, colonisation of breast tissue by F. nucleatum is secondary to tumour initiation, using Fap2 adhesion to silence cytotoxic immune cells and reduce infiltration of CD4 + and CD8 + T cells into “infected tumours.” The data also support that F. nucleatum accelerates tumour growth and metastatic progression (Parhi et al., 2020). Here, CD4 is linked to neoplasm.