BRCA2 and obesity due to melanocortin 4 receptor deficiency: Gut and breast dysbiosis are probably a reflection of exogenous factors (e.g., hormone replacement therapy, heavy alcohol use), but also a result of the influence of endogenous factors related to the host itself (e.g., ethnicity, overweight and obesity, menopausal state, BRCA1/BRCA2 genetic mutations), many of them established risk factors for BC (Cardoso et al., 2019).