SL-PYY(1-36) treatment reduced (p < 0.05 - p < 0.001) glucose concentrations in both mouse models, specifically, reversing and substantially delaying overt hyperglycaemia in GluCreERT2;Rosa26-eYFP and Ins1Cre/+;Rosa26-eYFP mice, respectively (Figures 2A, B). Here, PYY is linked to Hyperglycemia.