NLRP3 and familial hyperaldosteronism: Consistently, pre-treatment with the Rev-erb agonist SR9009 prevents LPS/GalN-induced FH pathogenesis by inhibiting the NLRP3 inflammasome pathway and CCL2 expression, thereby delaying death and improving the survival rate from 10% in the control to 70% in the SR9009-treated mice (132).