IAPP and early-onset autosomal dominant Alzheimer disease: Accordingly, oxidized LDL (oxLDL), but also islet amyloid polypeptide (IAPP) and Alzheimer Disease beta amyloid peptides (Aβ1–42), induce Nlrp3 and Il1β gene expression, and thus the priming of this pathway in a CD36-TLR2-TLR4 heterotrimer-dependent manner in bone marrow-derived macrophages (BMDM) (19, 20) (Figure 1).