Remarkably, clock disruption alters NLRP3 circadian oscillations in a mouse model of jetlag or in genetic and pharmacological models of clock alteration, thus modulating the progression of inflammatory diseases (3) including colitis (126), myocardial infarction/ischemia–reperfusion injury (162), lung injury (127) and fulminant hepatitis (132, 133). Here, CLOCK is linked to Fulminant hepatitis.