Thus, we analyzed the association between serum PRL levels and clinical parameters, such as waist circumference (WC), hip circumference (HC), luteinizing hormone (LH), triglyceride (TG), or the homeostasis model assessment of insulin resistance (HOMA-IR), in infertile PCOS patients by a retrospective cross-sectional study, to explore the status of PRL secretion and association with insulin resistance and beta-cell function. This evidence concerns the gene PRL and polycystic ovary syndrome.