POI is characterized by a hypergonadotropic hypogonadism state, which can be diagnosed by a triad of features in a woman under the age of 40: (a) postmenopausal levels of follicle-stimulating hormone (FSH) (>40 UI/L in two different samples taken separately in the time), (b) 4 or more months of amenorrhea, and (c) decreased estradiol serum concentrations (3). Here, BRD2 is linked to amenorrhea.