The data revealed that SHCBP1 levels were suggestively correlated with age (P = 0.009), multifocality (P = 0.024), and lymph node metastasis (P = 0.010), whereas no significant correlations were observed between SHCBP1expression levels and gender (P = 0.529), extrathyroidal extension (P = 0.440), infiltration depth (P = 0.270), distant metastasis (P = 0.312), as well as AJCC TNM Stage (P = 0.297) of the PTC patients (Table 1). The gene discussed is SHCBP1; the disease is metastatic malignant neoplasm in the lymph nodes.