A meta-analysis of the efficacy of ACTH in the treatment of glomerular diseases was carried out and revealed an 86% (25 out of 29 patients) remission rate for patients with iMN, who were converted to ACTH monotherapy after having failed other immunosuppressive therapy including glucocorticoids (Kittanamongkolchai et al., 2016). The gene discussed is POMC; the disease is glomerular disorder.