At that time, ACTH was believed to act mainly via adrenocortical steroidogenesis, and thus had been widely used in the treatment of a number of inflammatory or autoimmune disorders, including rheumatoid arthritis (RA), gout, lupus, rheumatic fever, psoriasis, and ulcerative colitis (Gallo-Payet, 2016). This evidence concerns the gene POMC and rheumatoid arthritis.