NDP and systemic lupus erythematosus: On the contrary, in a murine lupus-like model induced by pristane, NDP-MSH treatment did not reduce proteinuria or albuminuria, but it did improve histological markers of renal injury like glomerular IgG deposition and did reduce lupus activity, marked by reduction in hypergammaglobulinemia, anti-nuclear antibodies, and anti-neutrophil cytoplasmic plasma antibodies (Botte et al., 2014).