Evans et al. (2009) showed that angiotensin-II (Ang-II)-induced Ca2+ influx was significantly enhanced in cultured aortic VSMC from Goto-Kakizaki (GK) rats, a model of type 2 diabetes, when compared with cells from Wistar-Kyoto (WKY) control rats. This evidence concerns the gene AGT and type 2 diabetes mellitus.