TRPV4 and Hyperglycemia: Similarly, in db/db and STZ -induced diabetic C57BLKS/J mice, mRNA and protein levels of TRPV4 were significantly decreased in aortas, indicating that hyperglycemia is a crucial factor for the diminished TRPV4 expression, and impairs the endothelium-dependent vasodilation observed in diabetic mice (Gao et al., 2020).