BR may reduce the hypertension severity and elicits cytoprotection by lowering oxidative stress, preventing vascular NADPH oxidase activation, inhibiting lipid peroxidation and peroxynitrite-mediated oxidations, protecting against H2O2 toxicity, increasing NO half-life, and inhibiting iNOS (Kwak et al., 1991; Minetti et al., 1998; Wang et al., 2004). This evidence concerns the gene NOS2 and hypertensive disorder.