AGT and hypertensive disorder: Thus, AngII, via AT1 receptor, is associated with cell growth, inflammation, vasoconstriction, apoptosis, and production of extracellular matrix components and reactive oxygen species (ROS) (Kim et al., 2011; Savoia and Volpe, 2011); moreover, AngII also recruits monocytes and other inflammatory cells in heart, vasculature, and kidney during hypertension (Rucker and Crowley, 2017).