The Ren-2 transgenic rat is a model of Ang II-related hypertension, which means that the different effects of sEH inhibition between the Ren-2 transgenic and Han SD rats revealed the importance of the interaction of hypertension, renin–angiotensin system (RAS), and CYP-derived metabolites in the progression of CHF-related mortality. This evidence concerns the gene REN and hypertensive disorder.