Moreover, Xie showed that lncRNA-H19 expression was significantly upregulated in TGF-β2-induced HK-2 cell fibrosis and unilateral ureteral obstruction (UUO)-induced renal fibrosis in vivo, indicating that H19 upregulation contributes to renal fibrosis (Xie et al., 2016). This evidence concerns the gene H19 and renal fibrosis.