Both clinical and animal experiments show that HIIT can evoke higher levels of brain-derived neurotrophic factor (BDNF) production to improve the brain function in health, diabetics, and stroke patients (Afzalpour et al., 2015; Tonoli et al., 2015; Saucedo Marquez et al., 2015; Di Battista et al., 2018; Freitas et al., 2018; Boyne et al., 2019). Here, BDNF is linked to stroke disorder.