PFKFB3 and COVID-19: HIF-1α can regulate the activity of genes related to glucose transport and processing (LDH-A, PFKFB3, GLUT-1, PKM2), which seems to be overexpressed in monocytes from COVID-19 patients, but not at the same intensity as influenza virus and RSV-infected monocytes (Codo et al., 2020).