To begin to understand if PCP proteins have functional relevance in glomerular disease, two studies have specifically deleted VANGL2 from podocytes in mouse, which in adulthood, results in no discernible changes to the ultrastructure of the filtration barrier or significant impairment of renal function (Rocque et al., 2015; Papakrivopoulou et al., 2018). Here, VANGL2 is linked to glomerular disorder.