Despite the benefits of adipokine in protecting against metabolic diseases such as obesity and diabetes (Jortay et al., 2012; Martinez-Huenchullan et al., 2020), it is important to note that there are different adiponectin isoforms with functions that are not entirely clear, and exercise seems to regulate each isoform differently (Gerosa-Neto et al., 2016; Martinez-Huenchullan et al., 2018). The gene discussed is ADIPOQ; the disease is obesity due to melanocortin 4 receptor deficiency.