TTN and cardiomyopathy: Furthermore, FHL2 is involved in sarcomere integrity, partly through interaction with actin and titin (Johannessen et al., 2006), and FHL2 mutations are associated with both dilated (Arimura et al., 2007) and hypertrophic (Friedrich et al., 2014) cardiomyopathy, and FHL2 is thus believed to contain cardioprotective properties.