IFNG and COVID-19: However, after a manual curation of GO terms related to the immunopathology of severe COVID-19, the most significant GO: biological processes were neutrophil degranulation (2.8 × 10−60), granulocyte activation (3.9 × 10−60), myeloid leukocyte mediated immunity (3.7 × 10−56), inflammatory response (8.5 × 10−9), blood coagulation (2.0 × 10−7), T-cell activation (3.6 × 10−7), response to interferon-gamma (1.9 × 10−7), platelet degranulation (8.6 × 10−7), and acute inflammatory response (6.6 × 10−5).