According to Kost-Alimova et al., elevated mucin-1 (MUC1) protein levels predict acute lung injury and ARDS with poor clinical outcomes, and fostamatinib has been shown to reduce MUC1 abundance in a relevant pre-clinical model and has demonstrated safety profile in patients (Kost-Alimova et al., 2020; Tabassum et al., 2020). Here, MUC1 is linked to acute respiratory distress syndrome.