Aliskiren had an AUROC affinity of 0.993 on CTSD, and it is a renin inhibitor used to treat hypertension; torasemide had an AUROC affinity of 1.0 on EGFR, and it is used to treat edema associated with heart, renal, and hepatic failures; and triamterene had an AUROC affinity of 1.0 on EGFR, and it is used to treat hypertension. Here, REN is linked to hypertensive disorder.