Lastly, the most significant Reactome signaling pathways related to severe COVID-19 were neutrophil degranulation (2.3 × 10−60), innate immune system (1.8 × 10−43), hemostasis (1.0 × 10−12), signaling by VEGF (5.9 × 10−7), insulin-like growth factor (6.8 × 10−7), and platelet degranulation (4.9 × 10−6) (Supplementary Table S5). The gene discussed is VEGFA; the disease is COVID-19.