In Anglian (Anglian Breast Cancer Study Group, 2000) and US non-Hispanic white families (Whittemore et al., 2004), the frequency of pathogenic BRCA1/2 variants range between 1:400 and 1:500 in the general population, while the highest observed frequency is about 1:40 in the Ashkenazi-Jewish community (King et al., 2003; Dillenburg et al., 2012). This evidence concerns the gene BRCA1 and breast cancer.