Modifications such as, optical transducers (Dey and Goswami, 2011), electrochemical (Grieshaber et al., 2008), piezoelectric biotransducers (Pohanka, 2018), thermometric and magnetic-based transducers etc. have been employed by various researchers for targeting BRCA1 (Culha et al., 2004; Benvidi et al., 2015), HER-2 (Chang et al., 2011; Marques et al., 2014), MUC1 (Chang et al., 2011; Hu et al., 2014), miR-21 (Torrente-Rodríguez et al., 2015; Li D. et al., 2016), EpCAM (Arya et al., 2013), etc., in early BC detection. The gene discussed is ERBB2; the disease is breast cancer.