In human cancers, the p53 gene is the most mutated gene that encodes at least 12 TP53 isoforms (p53α, p53β, p53γ, Δ40p53α, Δ40p53β, Δ40p53γ, Δ133p53α, Δ133p53β, Δ133p53γ, Δ160p53α, Δ160p53β, and Δ160p53γ) of varying sizes from 11 exons (Kim and An, 2016). This evidence concerns the gene TP53 and cancer.