Several researchers have designed aptamer for HER2 (Chun et al., 2013; Qureshi et al., 2015), EpCAM (Song et al., 2013), MUC1 (He et al., 2012; Hu et al., 2014), VEGF (Zhao et al., 2011) and nucleolin (Feng et al., 2011) for early BC detection. This evidence concerns the gene ERBB2 and breast cancer.