With the advancement in technologies, such as serological proteome assay (SERPA), serological analysis of tumor antigens by recombinant DNA (cDNA) expression cloning (SEREX), multiple affinity protein profiling (MAPPing), and many more, novel immune biomarkers of BC have been discovered and utilized in the early detection of antigens such as TP53, HSP60, Mn-SOD, cyc-B1, c-myc, and so forth (Hamrita et al., 2008). Here, TP53 is linked to breast cancer.